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The Humane Society of the United States has revealed the results of an investigation into an animal testing lab in Indiana with ties to Maryland and Virginia, saying 80 beagle puppies are being used in toxicity tests in addition thousands of other animals, including primates, pigs, mice and rats.
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The Humane Society said it conducted a secret investigation into the company Inotiv, which has ties to Rockville, where an investigator was employed at the facility and assigned to work on more than 70 toxicity studies commissioned by more than two dozen pharmaceutical companies involving more than 6,000 animals. . Read the full report here.
They say 80 beagle puppies are still being used in toxicity tests that involve forcing them to ingest a drug through a stomach tube every day for months. The Humane Society says the first wave of dogs should be killed in mid-May.
The society’s dog-breeding facility in Cumberland, Va., has been cited for numerous animal welfare law violations, according to the Humane Society, prompting the Virginia legislature to pass five bills aimed at to increase the protection of animals in laboratory breeding establishments, recently enacted. by Governor Glenn Youngkin.
The Humane Society is calling for the immediate release of the beagles from the lab and they are planning a demonstration on Friday in front of a location in Rockville that Inotiv is occupying.
PHOTO: Humane Society of the United States
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In addition to beagle puppies, the Humane Society says their investigation also led to the following findings:
– At least two primates accidentally hanged themselves in restraint chairs
– Dogs continued to be dosed with the substances even when they were vomiting, shaking, and had high fevers and labored breathing
– The lab vet did not always assess or treat seriously ill dogs and primates, some groaning in pain, due to personal inconvenience
– Most animals were killed at the end of the studies, as is the case with any drug test
PHOTO: Humane Society of the United States
The Humane Society of the United States and the Humane Society Legislative Fund are calling on the Food and Drug Administration and pharmaceutical companies to replace animals with more efficient, non-animal testing approaches that will better serve humans while sparing animals.
The Humane Society says nearly 90% of drugs tested on animals ultimately fail in human trials, with about half of those failures due to unforeseen human toxicity, although no toxicity has been observed in human trials. animals.
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They claim that there is evidence that non-animal approaches, such as organic chip technologies, artificial intelligence, 3D printing, and various other approaches, alone or in combination, provide superior results that will ultimately improve rates. success of drugs for humans while sparing animals.
“The disturbing findings from this facility cannot be ignored. We are calling for the release of the beagles we know are suffering from in the lab today and will soon be euthanized, but this is just the start of our work,” said Kitty Block, CEO and president of the Humane Society of the United States. “We need to get to the root cause of this suffering. This seems to be one of the only areas of science where the failure to innovate and bring about change is accepted and, at times, encouraged. We hope that sharing the fate of these animals to accelerate changes by the FDA and the pharmaceutical industry to replace outdated animal testing with superior modern technologies.”
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“Our federal government needs to invest in good science in the form of effective, humane, non-animal testing methods to replace these tragic animal tests. In many cases, non-animal testing is more reliable, faster, and more cost-effective. than existing animal methods are generally accepted by our federal government,” said Sara Amundson, president of the Humane Society Legislative Fund. “It is time for the FDA to accelerate the move away from animal testing in the regulated sector. We must ensure a better future for animals and people.”
Inotiv sent FOX 5 the following statement regarding the Humane Society of the United States report:
“In the United States, any drug under development must be tested in a controlled environment to properly assess its safety before being tested on humans. These federally required tests are part of agency-mandated scientific research governmental organizations in the United States and around the world,” the statement read. “Inotev provides biomedical research services to companies developing life-saving treatments that span a range of human diseases. At our Indiana facility, the drug being tested, if successful, will treat a specific rare disease affecting newborns, infants and children.This drug must be tested and confirmed to be safe both in terms of toxicity and dosage before proceeding to clinical trials in humans.For more information on the mandated drug development process by the federal government, please find below several links to government information and other publicly available resources along with all applicable federal, state, and local regulations, as well as animal welfare law, and, in our facilities in Indiana and Maryland, is accredited by AAALAC, the Association for the Accreditation and Assessment of Laboratory Animal Care International national.